Orally delivered siRNA
نویسندگان
چکیده
منابع مشابه
Retrovirus-delivered siRNA
BACKGROUND The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells. However, high production costs limit this technology's utility for many laboratories and experimental situations. Recently, several DNA-based plasmid vectors have been developed that direct transcr...
متن کاملOrally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines.
Small interfering RNAs (siRNAs) directed against proinflammatory cytokines have the potential to treat numerous diseases associated with intestinal inflammation; however, the side-effects caused by the systemic depletion of cytokines demands that the delivery of cytokine-targeted siRNAs be localized to diseased intestinal tissues. Although various delivery vehicles have been developed to orally...
متن کاملModeling Impact of Ingested Lipids on Orally Delivered Drug Dissolution
Introduction Ingested lipids could offer valuable opportunities for enabling oral drug delivery, as approximately 4070% of all new drug candidates have been estimated to have very poor water solubility and are expected to exhibit low bioavailability when orally dosed. For hydrophobic drug molecules, the dissolution process in water is likely the limiting step of overall oral absorption. Therefo...
متن کاملGinsan Enhances Humoral Antibody Response to Orally Delivered Antigen
BACKGROUND There have been several reports describing the capability of ginseng extracts as an adjuvant. In this study, we tested if ginsan, a polysaccharide extracted from Panax ginseng, was effective in enhancing antibody response to orally delivered Salmonella antigen. METHODS Ginsan was treated before oral salmonella antigen administration. Salmonella specific antibody was determined by E...
متن کاملOrally Delivered Decitabine Loaded PLGA Nanoparticles Combined with Docetaxel Supress Solid Tumours: an in vitro investigation
Docetaxel is one of the greatest chemotherapeutic agent used in the treatment of solid tumours. However, resistance to docetaxel is a major clinical issue, which obstacle to achieve long time survival for patients with advanced disease. The inherent presence or emergence of drug-resistant tumour clones confines its efficiency in the treatment of cancers. The understanding that epigenetic change...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2009
ISSN: 1945-3477
DOI: 10.1038/scibx.2009.817